Oleandrin

Oleandrin is a glycoside that has been found in N. oleander and has diverse biological activities. It inhibits NF-kappaB activation induced by hydrogen peroxide, LPS, okadaic acid (Cay-10011490), ceramide, or TNF in U937 cells when used at a concentration of 1 µg/ml. Oleandrin inhibits transmissible gastroenteritis virus (TGEV) replication without inducing cytotoxicity in swine testis cells (IC50 = 147 nM). It reduces pyramidal neuron cell death induced by oxygen-glucose deprivation (OGD) in cultured rat brain explant slices. Oleandrin reduces viability and inhibits migration of U87MG, A172, U251, and GBM19 glioma cells. In vivo, oleandrin (0.3 mg/kg) reduces tumor size and increases survival in U78MG, GL261, and U251 glioma mouse xenograft models.Formal Name: (3beta,5beta,16beta)-16-(acetyloxy)-3-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide. CAS Number: 465-16-7. Synonyms: Folinerin, Neriolin. Molecular Formula: C32H48O9. Formula Weight: 576.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. SMILES: CO[C@@H](C1)[C@@H](O)[C@H](C)O[C@H]1O[C@H](C2)CC[C@@]3(C)[C@]2([H])CC[C@]4([H])[C@]3([H])CC[C@@]5(C)[C@]4(O)C[C@H](OC(C)=O)[C@]5([H])C6=CC(OC6)=O. InChi Code: InChI=1S/C32H48O9/c1-17-29(35)24(37-5)14-27(39-17)41-21-8-10-30(3)20(13-21)6-7-23-22(30)9-11-31(4)28(19-12-26(34)38-16-19)25(40-18(2)33)15-32(23,31)36/h12,17,20-25,27-29,35-36H,6-11,13-16H2,1-5H3/t17-,20+,21-,22-,23+,24-,25-,27-,28-,29-,30-,31+,32-/m0/s1. InChi Key: JLPDBLFIVFSOCC-XYXFTTADSA-N. Origin: Plant/Nerium oleander.