Obidoxime (chloride)

Obidoxime is an acetylcholinesterase (AChE) modulator. It induces inhibition and activation of bovine erythrocyte AChE in the presence and absence of ACh, respectively, when used at a concentration of 3 mM. Obidoxime (10.5 mg/kg) induces reactivation of tabun-inhibited AChE in rat blood and diaphragm and reduces tabun-induced lethality in mice. Intranasal administration of obidoxime reduces seizure duration and severity and prevents mortality in a rat model of paraoxon-induced organophosphate poisoning.Formal Name: 1,1'-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-pyridinium, dichloride. CAS Number: 114-90-9. Synonyms: Toxogonin. Molecular Formula: C14H16N4O3 . 2Cl. Formula Weight: 359.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly Soluble, DMSO: Slightly Soluble, PBS (pH 7.2): 10 mg/ml. lambdamax: 301 nm. SMILES: ON=CC1=CC=[N+](COC[N+]2=CC=C(C=C2)C=NO)C=C1.[Cl-].[Cl-]. InChi Code: InChI=1S/C14H14N4O3.2ClH/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20,,/h1-10H,11-12H2,2*1H. InChi Key: ZIFJVJZWVSPZLE-UHFFFAOYSA-N.