NX-1607

An inhibitor of Cbl-b (IC50 = 3.4 nM), increases IL-2 secretion in primary human T cells (EC50 = 180.6 nM), application of NX-1607 to anti-CD19 CAR-T cells generated from patients with DLBCL increases the number of CAR-T cells formed during expansion, increases the production of IFN-gamma, TNF-alpha, IL-2, and granzyme B in anti-CD19 CAR-T cells, enhances the cytotoxicity of anti-CD19 CAR-T cells in Raji, Daudi, and SU-DHL-4 cells, reduces ALT and AST, markers of liver injury, and hepatic fibrosis in MCD diet, CCl4, and BDL models of liver fibrosis at 5 mg/kg. SMILES: O=C1C2=CC(CN3C[C@H](CCC3)C)=CC(C(F)(F)F)=C2CN1C4=CC=CC([C@@]5(C6=NN=CN6C)C[C@@H](C5)C)=C4. InChi Code: InChI=1S/C30H34F3N5O/c1-19-6-5-9-37(15-19)16-21-10-24-25(26(11-21)30(31,32)33)17-38(27(24)39)23-8-4-7-22(12-23)29(13-20(2)14-29)28-35-34-18-36(28)3/h4,7-8,10-12,18-20H,5-6,9,13-17H2,1-3H3/t19-,20-,29+/m0/s1. InChi Key: HUOLMBXGHHSYHC-QWQFASRJSA-N