NVP-LCQ195
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NVP-LCQ195 is an inhibitor of cyclin-dependent kinases (CDKs). It selectively inhibits Cdk5/p25,... more
Product information "NVP-LCQ195"
NVP-LCQ195 is an inhibitor of cyclin-dependent kinases (CDKs). It selectively inhibits Cdk5/p25, Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin A, and Cdk2/cyclin E complexes (IC50s = 1, 1, 2, 2, and 5 nM, respectively) over Cdk9/cyclin T1, Cdk3/cyclin E, Cdk6/cyclin D3, and Cdk7/cyclin H complexes (IC50s = 15, 42, 187, and 3,564 nM, respectively). NVP-LCQ195 decreases viability in a panel of 25 multiple myeloma cells (EC50s = 0.761-2. µM). It induces cell cycle arrest at the G0 phase and apoptosis in MM.1S multiple myeloma cells when used at a concentration of 2 µM.. Solulibility: Ethanol: Slightly soluble: 0.1-1 mg/ml: .
| Keywords: | AT-9311, LCQ-195, 4-[(2,6-dichlorobenzoyl)amino]-N-[1-(methylsulfonyl)-4-piperidinyl]-1H-pyrazole-3-carboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 42728 |
Properties
| Application: | CDK inhibitor |
| MW: | 460.33 D |
| Formula: | C17H19Cl2N5O4S |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 902156-99-4| Matching products |
| KEGG ID : | K02090 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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