NVP-BEZ235

NVP-BEZ235
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-CR1-3633-M005 5 mg -

3 - 9 business days*

33.00€
AG-CR1-3633-M025 25 mg -

3 - 9 business days*

83.00€
 
White to off-white solid. Soluble in dimethylformamide (~10mg/ml). Sligthly soluble in DMSO or... more
Product information "NVP-BEZ235"
White to off-white solid. Soluble in dimethylformamide (~10mg/ml). Sligthly soluble in DMSO or chloroform (~1mg/ml). Warming and sonication might be necessary. Insoluble in water. Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays, Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, , Enhances the efficacy of other anticancer agents when used in in vivo combination studies, Strongly inhibits VEGF-induced cell proliferation and survival in vitro and VEGF-induced angiogenesis in vivo, Shown to be a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage and DNA double-strand break repair, Shown to have neuroprotective properties on amyloid-beta 1-42 induced neurotoxicity and memory impairment, Shows anti-trypanosomal activity for some selected species.
Keywords: Dactolisib, BEZ235, 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-alpha,alpha-dimethyl-benzeneacetonitrile
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-CR1-3633

Properties

Application: Potent dual ATP-competitive pan class I PI3K & mTOR inhibitor
MW: 469,5 D
Formula: C30H23N5O
Purity: >98%
Format: Solid

Database Information

CAS : 915019-65-7| Matching products
KEGG ID : K00922 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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