(+)-Nutlin-3

(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585). It inhibits the interaction between p53 and Mdm2 150-fold less potently than (-)-nutlin-3 with an IC50 value of 13.6 µM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (-)-nutlin-3 in cancer cells.Formal Name: 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone. CAS Number: 675576-97-3. Synonyms: Nutlin 3b. Molecular Formula: C30H30Cl2N4O4. Formula Weight: 581.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMSO: 14 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH7.2) (1:7): 0.12 mg/ml. SMILES: ClC1=CC=C([C@H]2[C@@H](C3=CC=C(Cl)C=C3)N=C(C4=CC=C(OC)C=C4OC(C)C)N2C(N5CCN([H])C(C5)=O)=O)C=C1. InChi Code: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1. InChi Key: BDUHCSBCVGXTJM-IZLXSDGUSA-N.