NS 3623

NS 3623 is an ion channel modulator. It inhibits the volume-regulated anion channel (VRAC) in HEK293 cells and chloride conductance in isolated human red blood cells (IC50s = 1.8 and 0.21 µM, respectively). NS 3623 also activates human-ether-a-go-go (hERG), also known as Kv11.1 (EC50 = 79.4 µM) but does not activate the voltage-gated potassium channel (Kv) subtypes Kv1.5, Kv4.3, or Kv7.1 at 30 µM. It increases red blood cell density and improves red blood cell morphology in the SAD transgenic mouse model of sickle cell disease when administered at a dose of 100 mg/kg per day for 21 days. NS 3623 (50 mg/kg) reverses QT interval prolongation induced by the hERG inhibitor E-4031 (Cay-15203) in conscious guinea pigs.Formal Name: N-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea. CAS Number: 343630-41-1. Molecular Formula: C15H10BrF3N6O. Formula Weight: 427.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 1 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. lambdamax: 227, 245, 271, 381 nm.