NS 1738

NS 1738 is a positive allosteric modulator of the alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through alpha7-containing nAChRs (EC50 = 3.4 µM). NS 1738 displays no substantial activity for alpha4beta2-, alpha3beta3-, and alpha1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of alpha7-containing nAChRs in signaling pathways.Formal Name: N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-urea. CAS Number: 501684-93-1. Synonyms: NSC 213859. Molecular Formula: C14H9Cl2F3N2O2. Formula Weight: 365.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 209, 263, 296 nm. SMILES: ClC1=C(C=C(C=C1)C(F)(F)F)NC(NC2=C(C=CC(Cl)=C2)O)=O. InChi Code: InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23). InChi Key: OUDXRNQPVSMGDW-UHFFFAOYSA-N.