35 products were found matching "K04809"!

B-973B is an allosteric agonist and positive allosteric modulator (ago-PAM) of alpha7 nicotinic acetylcholine receptors (nAChRs). It enhances ACh-induced activation in a two-electrode voltage-clamp assay using Xenopus oocytes expressing the human alpha7 nAChR when used at a concentration of 10 µM. B-973B (10 mg/kg)...

CCMI is a positive allosteric modulator (PAM) of alpha7 nicotinic acetylcholine receptors (nAChRs). It enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human alpha7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively). In vivo, CCMI (0.3 and 1 mg/kg, i.v.) improves...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CHRNa7. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CHRNa7....

(±)-Anatoxin A is a bicyclic amine isolated from the blue-green alga A. aquae that displays high affinity for nicotinic acetylcholine receptors (Kd = 0.1-0.2 µM). It binds alpha4beta2- and alpha7-type nicotinic receptors with Ki values of 1.3 nM and 1.8 µM, respectively, and stimulates [3H]-dopamine release from...

GTS-21 is an agonist of alpha7-containing nicotinic acetylcholine receptors (nAChRs) that, at a concentration of 100 µM, activates human alpha7-containing nAChRs expressed in Xenopus oocytes to 60% of the levels generated by endogenous ligand acetylcholine. It is selective for alpha7-containing nAChRs, having no...

(±)-Nornicotine is an active metabolite of nicotine (Cay-16535) and a nicotinic acetylcholine receptor (nAChR) agonist. It induces currents in Xenopus oocytes expressing human alpha7 nAChRs or alpha6 subunit-containing nAChRs (EC50s = 17 and 3.7 µM, respectively). (±)-Nornicotine promotes cell migration and...

Methyllycaconitine (MLA) is an antagonist of alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs, Ki = 1.4 nM). It is less effective at other nAChRs. MLA is used to selectively evaluate the role of alpha7-containing nAChRs in signaling pathways.Formal Name:...

NS 1738 is a positive allosteric modulator of the alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through alpha7-containing nAChRs (EC50 = 3.4 µM). NS 1738 displays no substantial activity for...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cholinergic receptor, nicotinic, alpha 7 Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of...

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a...

PNU 120596 is a positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM). It has no detectable effect on alpha4beta2, alpha3beta4, or alpha9beta10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic...

(-)-Nicotine is an alkaloid that has been found in tobacco. It is an agonist at neuronal nicotinic acetylcholine receptors (nAChRs) and binds to alpha3beta4 and alpha4beta2 subunit-containing nAChRs with Ki values of 481 and 11.1 nM, respectively. Chronic exposure to (-)-nicotine results in increased expression of...