57 products were found matching "K04809"!

Rabbit Polyclonal CHRNA7 Antibody against Human cholinergic receptor nicotinic alpha 7 subunit. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000030525:...

(±)-Anatoxin A is a bicyclic amine isolated from the blue-green alga A. aquae that displays high affinity for nicotinic acetylcholine receptors (Kd = 0.1-0.2 µM). It binds alpha4beta2- and alpha7-type nicotinic receptors with Ki values of 1.3 nM and 1.8 µM, respectively, and stimulates [3H]-dopamine release from...

An agonist of a7 nAChRs, induces inward currents in Xenopus oocytes expressing the rat or human receptor (EC50s = 2.45 and 4.26 µM, respectively), which can be reversed by methyllycaconitine, selectively binds to a7 nAChRs (Kis = 10.8 and 16.7 nM for the rat and human receptors, respectively) over a panel of >75...

An agonist of alpha7 nAChRs, selective for alpha7 nAChRs over alpha4beta2-, alpha4beta4-, alpha3beta2-, or alpha3beta4 subunit-containing nAChRs and 5-HT3 (EC50s = 0.03, >100, >50, >100, >100, and 11 µM, respectively, in calcium mobilization assays), prevents decreases in the number of retinal ganglion cells in a...

DMAB-anabaseine is a partial agonist of alpha7 nicotinic acetylcholine receptors (nAChRs). It induces currents in a whole-cell patch-clamp assay using Xenopus oocytes expressing human alpha7 nAChRs (EC50 = 21 µM). Intracerebroventricular administration of DMAB-anabaseine (80 µg/animal) inhibits nicotine-induced...

GTS-21 is an agonist of alpha7-containing nicotinic acetylcholine receptors (nAChRs) that, at a concentration of 100 µM, activates human alpha7-containing nAChRs expressed in Xenopus oocytes to 60% of the levels generated by endogenous ligand acetylcholine. It is selective for alpha7-containing nAChRs, having no...

Methyllycaconitine (MLA) is an antagonist of alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs, Ki = 1.4 nM). It is less effective at other nAChRs. MLA is used to selectively evaluate the role of alpha7-containing nAChRs in signaling pathways.Formal Name:...

(±)-Nornicotine is an active metabolite of nicotine (Cay-16535) and a nicotinic acetylcholine receptor (nAChR) agonist. It induces currents in Xenopus oocytes expressing human alpha7 nAChRs or alpha6 subunit-containing nAChRs (EC50s = 17 and 3.7 µM, respectively). (±)-Nornicotine promotes cell migration and...

NS 1738 is a positive allosteric modulator of the alpha7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through alpha7-containing nAChRs (EC50 = 3.4 µM). NS 1738 displays no substantial activity for...

CCMI is a positive allosteric modulator (PAM) of alpha7 nicotinic acetylcholine receptors (nAChRs). It enhances ACh-, nicotine-, or choline-induced currents in Xenopus oocytes expressing recombinant human alpha7 nAChRs (EC50s = 0.7, 0.6, and 0.5 µM, respectively). In vivo, CCMI (0.3 and 1 mg/kg, i.v.) improves...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cholinergic receptor, nicotinic, alpha 7 Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of...

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a...