NP-118809

NP-118809 is an inhibitor of N-type voltage-gated calcium channels (IC50 = 0.11 µM). It is selective for N-type over L-type voltage-gated calcium channels and human-ether-a-go-go (hERG), also known as Kv11.1 (IC50s = 12.2 and 7.4 µM, respectively), as well as a panel of 112 other ion channels, receptors, and signaling targets at 10 µM. NP-118809 (25 mg/kg, i.p.) decreases the number of flinches in the second phase of the formalin test in a rat model of inflammatory pain.Formal Name: 1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone. CAS Number: 41332-24-5. Synonyms: MK-6721. Molecular Formula: C32H32N2O. Formula Weight: 460.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml. SMILES: O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)N3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3. InChi Code: InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2. InChi Key: VCPMZDWBEWTGNW-UHFFFAOYSA-N.