NOD-IN-1

NOD-IN-1 is an inhibitor of nucleotide-binding oligomerization domain (NOD) receptors and a derivative of nodinitib-1 (Cay-11040). NOD-IN-1 inhibits C12-iE-DAP-induced NF-?B activation in HEK-Blue cells expressing human recombinant NOD1 or NOD2 (IC50s = 5.74 and 6.45 µM, respectively).Formal Name: 1-[(4-methylphenyl)sulfonyl]-1H-indole-2-carboxylic acid, ethyl ester. CAS Number: 132819-92-2. Molecular Formula: C18H17NO4S. Formula Weight: 343.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 216, 271 nm. SMILES: O=C(OCC)C1=CC2=CC=CC=C2N1S(C3=CC=C(C)C=C3)(=O)=O. InChi Code: InChI=1S/C18H17NO4S/c1-3-23-18(20)17-12-14-6-4-5-7-16(14)19(17)24(21,22)15-10-8-13(2)9-11-15/h4-12H,3H2,1-2H3. InChi Key: OJMOGUKIYRAILM-UHFFFAOYSA-N.