Description: NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors. Target: NOD-like Receptor (NLR), NOD. Smiles: CCOC(=O)c1cc2ccccc2n1S(=O)(=O)c1ccc(C)cc1. References: Kecek Plesec K, et al. Identification of indole scaffold-based dual inhibitors of...

NOD-IN-1 is an inhibitor of nucleotide-binding oligomerization domain (NOD) receptors and a derivative of nodinitib-1 (Cay-11040). NOD-IN-1 inhibits C12-iE-DAP-induced NF-?B activation in HEK-Blue cells expressing human recombinant NOD1 or NOD2 (IC50s = 5.74 and 6.45 µM, respectively).Formal Name:...