NO-Pravastatin

NO-pravastatin is a derivative of pravastatin (Cay10010343) that contains a nitric oxide-releasing moiety. It induces cGMP formation in PC12 cells (EC50 = 2.3 µM) and inhibits the proliferation of isolated rat aortic smooth muscle cells (IC50 = 2.2 µM). NO-pravastatin reduces inducible nitric oxide synthase (iNOS) and COX-2 levels in LPS-stimulated RAW 264.7 cells. NO-pravastatin (48.5 mg/kg) reduces splenocyte adhesion to artery segments isolated from wild-type and ApoE-/- mice. It reduces infarct size in a mouse model of myocardial infarction when administered at a dose of 22.4 µmol/kg. NO-pravastatin (24-48 mg/kg) reduces platelet consumption, lung vessel occlusion, and mortality in mouse models of platelet pulmonary thromboembolism induced by collagen and epinephrine or U-46619 (Cay16450).. SMILES: O[C@H]1C[C@H](CC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CCC(O)C[C@@H](O)CC(OCCCCO[N+]([O-])=O)=O)=C1. InChi Code: InChI=1S/C28H45NO9/c1-4-18(2)26(33)15-21-14-23(31)13-20-8-7-19(3)25(28(20)21)10-9-22(30)16-24(32)17-27(34)37-11-5-6-12-38-29(35)36/h7-8,13,18-19,21-25,28,30-32H,4-6,9-12,14-17H2,1-3H3/t18-,19-,21+,22?,23+,24+,25-,28+/m0/s1. InChi Key: MTLUGMOLQVSLTL-LHGOKVPCSA-N