NLRP3-IN-9

Description: NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner. Target: NOD. Smiles: CCOC(=O)C(=C)C(O)c1ccccc1Cl. References: Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, Marini E, Fantozzi R, Miglio G, Bertinaria M. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26,57(24):10366-82. doi: 10.1021/jm501072b. Epub 2014 Dec 4. PubMed PMID: 25418070.