An NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome by 51.8% at 10 µM, inhibits caspase 1 (Ki = 10.6 µM), active against S. aureus, C. diphtheriae, K. pneumoniae, and E. coli, (MICs = 18, 18, 18, and 16 µg/ml, respectively) and the fungus C. albicans (MIC = 13 µg/ml), inhibits ATP-induced pyroptosis in...

Description: NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner. Target: NOD. Smiles:...