Nicotinic Acid

Nicotinic acid, also known as niacin, is an antagonist of hydroxycarboxylic acid receptor 2 (HCA2), known previously as GPR109A (Ki = 113 nM). Nicotinic acid reduces lipolysis in primary human adipocytes (IC50 = 200 nM). It reduces the invasion of AH109A-TC cancer cells when used at concentrations of 20 and 40 µM. Nicotinic acid increases cutaneous vasodilation in normotensive mice in a dose-dependent manner. Formulations containing nicotinic acid have been used in the treatment of hyperlipidemia.Formal Name: 3-pyridinecarboxylic acid. CAS Number: 59-67-6. Synonyms: Niacin, NSC 169454, Pyridine-3-Carboxylic Acid, SR 4390, Vitamin B3. Molecular Formula: C6H5NO2. Formula Weight: 123.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 217 nm. SMILES: O=C(C1=CN=CC=C1)O. InChi Code: InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9). InChi Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N.