Nicotinamide N-oxide

Nicotinamide N-oxide is a metabolite of nicotinamide (Cay-11127). It is formed via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT, Cay-17341), indicating cell differentiation, in HL-60 promyelocytic leukemia cells. Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.Formal Name: 3-pyridinecarboxamide, 1-oxide. CAS Number: 1986-81-8. Synonyms: NSC 168416, NSC 30531. Molecular Formula: C6H6N2O2. Formula Weight: 138.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: Partially soluble, DMSO: 3 mg/ml, Ethanol: Partially soluble, PBS (pH 7.2): 5 mg/ml. lambdamax: 222, 271 nm. SMILES: [O-][N+]1=CC=CC(C(N)=O)=C1. InChi Code: InChI=1S/C6H6N2O2/c7-6(9)5-2-1-3-8(10)4-5/h1-4H,(H2,7,9). InChi Key: USSFUVKEHXDAPM-UHFFFAOYSA-N. Origin: Synthetic.