NF 023

NF 023 is a purinergic P2X1 receptor antagonist (IC50 = 0.21 µM). It is selective for P2X1 over P2X2-4 receptors (IC50s = >50, 28.9 and >100 µM, respectively). It inhibits alpha,beta-methylene ATP-induced vasoconstriction in isolated rabbit saphenous arteries (pA2 = 5.69). NF 023 also inhibits hepatitis C virus (HCV) NS3 helicase (IC50 = 6.2 µM).Formal Name: 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid, hexasodium salt. CAS Number: 104869-31-0. Molecular Formula: C35H20N4O21S6 . 6Na. Formula Weight: 1162.9. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: Water: 100 mM. SMILES: [O-]S(C1=CC(S([O-])(=O)=O)=C(C(NC(C2=CC(NC(NC3=CC=CC(C(NC4=C(C(S([O-])(=O)=O)=CC(S([O-])(=O)=O)=C5)C5=C(S([O-])(=O)=O)C=C4)=O)=C3)=O)=CC=C2)=O)=CC=C6S([O-])(=O)=O)C6=C1)(=O)=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C35H26N4O21S6.6Na/c40-33(38-25-7-9-27(63(49,50)51)23-13-21(61(43,44)45)15-29(31(23)25)65(55,56)57)17-3-1-5-19(11-17)36-35(42)37-20-6-2-4-18(12-20)34(41)39-26-8-10-28(64(52,53)54)24-14-22(62(46,47)48)16-30(32(24)26)66(58,59)60,,,,,,/h1-16H,(H. InChi Key: FMQURVHYTBGYSQ-UHFFFAOYSA-H.