Nefazodone (hydrochloride)

Nefazodone is a serotonin (5-HT), norepinephrine, and dopamine reuptake inhibitor (SNDRI, Kis = 137, 570, 2,380 nM, respectively, in rat brain synaptosomes). It is also an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as alpha1- and alpha2-adrenergic receptors (alpha2-ARs, Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively). Nefazodone (100 mg/kg) reduces immobility time in the tail suspension test in gerbils. However, it is toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation when used at a concentration of 30 µM. Formulations containing nefazodone have previously been used in the treatment of depression.Formal Name: 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, monohydrochloride. CAS Number: 82752-99-6. Synonyms: BMY 13754, MJ13754-1. Molecular Formula: C25H32ClN5O2 . HCl. Formula Weight: 506.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: ClC1=CC(N2CCN(CCCN3C(N(CCOC4=CC=CC=C4)C(CC)=N3)=O)CC2)=CC=C1.Cl. InChi Code: InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22,/h3-6,8-11,20H,2,7,12-19H2,1H3,1H. InChi Key: DYCKFEBIOUQECE-UHFFFAOYSA-N.