NEDD8 Inhibitor M22

NEDD8 inhibitor M22 is an inhibitor of NEDD8-activating enzyme (NAE). It inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay using recombinant human NAE in a concentration-dependent manner. NEDD8 inhibitor M22 selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 non-small cell lung cancer (NSCLC) cells and inhibits the growth of A549 cells (GI50 = 5.5 µM). It inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model when administered at a dose of 60 mg/kg.Formal Name: N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine. CAS Number: 864420-54-2. Synonyms: NAE-IN-M22, NEDD8-activating Enzyme Inhibitor M22. Molecular Formula: C20H24Cl2N2. Formula Weight: 363.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: Slightly Soluble, Ethanol: 5 mg/ml. SMILES: ClC1=CC=C(CCNC2CCN(CC2)CC3=CC=CC=C3)C(Cl)=C1. InChi Code: InChI=1S/C20H24Cl2N2/c21-18-7-6-17(20(22)14-18)8-11-23-19-9-12-24(13-10-19)15-16-4-2-1-3-5-16/h1-7,14,19,23H,8-13,15H2. InChi Key: WMEXQHGRMWPOEF-UHFFFAOYSA-N.