Necrostatin-2

Necrostatin-2 is a potent inhibitor of necroptosis with an EC50 of 50 nM in Jurkat T cells deficient of Fas-associated protein with death domain (FADD) and treated with TNF-alpha. It is approximately 4-fold more active than the (S)-enantiomer (EC50 = 230 nM).Formal Name: 5R-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione. CAS Number: 852391-19-6. Synonyms: Cl-Necrostatin analog, Nec-2. Molecular Formula: C13H12ClN3O2. Formula Weight: 277.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.50 mg/ml, DMSO: 14 mg/ml, Ethanol: 3 mg/ml. lambdamax: 222, 283 nm. SMILES: O=C([C@H](N1)CC2=CNC3=C(Cl)C=CC=C32)N(C)C1=O. InChi Code: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1. InChi Key: WIKGAEMMNQTUGL-SNVBAGLBSA-N.