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Item number: Cay11657-1

Necrostatin-2 is a potent inhibitor of necroptosis with an EC50 of 50 nM in Jurkat T cells deficient of Fas-associated protein with death domain (FADD) and treated with TNF-alpha. It is approximately 4-fold more active than the (S)-enantiomer (EC50 = 230 nM).Formal Name:...

Keywords:	Cl-Necrostatin analog, 5R-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
Application:	Necroptosis inhibitor
CAS	852391-19-6
MW:	277.7 D

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Necrostatin 2

Item number: TGM-T12203L-1mL

Description: Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-alpha is 0.05 µM. Target: Others. Smiles: CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O. References: Teng X, et al....

CAS	852391-19-6
MW:	277.71 D

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