Nafamostat (mesylate)

Nafamostat (mesylate)
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14837-5 5 mg -

6 - 10 business days*

50.00€
Cay14837-10 10 mg -

6 - 10 business days*

92.00€
Cay14837-50 50 mg -

6 - 10 business days*

401.00€
 
Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive... more
Product information "Nafamostat (mesylate)"
Nafamostat is a serine protease inhibitor that is capable of inhibiting trypsin (a digestive system protease, Ki = 15 nM), tryptase (a mast cell protease, Ki = 95.3 pM), and additional proteases in the coagulation cascade including thrombin (Ki = 0.84 µM). In a mouse model of allergic asthma, a dose of 300 mg/kg nafamostat mesylate has been shown to inhibit serine proteolytic activity, to decrease circulating levels of eosinophils and lymphocytes in bronchoalveolar lavage fluid, and to reduce interleukin-13 and eotaxin production associated with antigen-induced airway eosinophilia and goblet cell hyperplasia.Formal Name: 4-[(aminoiminomethyl)amino]-benzoic acid, 6-(aminoiminomethyl)-2-naphthalenyl ester, dimethanesulfonate. CAS Number: 82956-11-4. Synonyms: Coahibitor, FUT 175, Nafamastat. Molecular Formula: C19H17N5O2 . 2CH3SO3H. Formula Weight: 539.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 243 nm. SMILES: NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O.CS(=O)(O)=O. InChi Code: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23,2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24),2*1H3,(H,2,3,4). InChi Key: SRXKIZXIRHMPFW-UHFFFAOYSA-N.
Keywords: Coahibitor, FUT 175, Nafamastat, 4-[(aminoiminomethyl)amino]-6-(aminoiminomethyl)-2-naphthalenyl ester-benzoic acid, dimethanesulfonate
Supplier: Cayman Chemical
Supplier-Nr: 14837

Properties

Application: Serine protease inhibitor
MW: 539.6 D
Formula: C19H17N5O2 . 2CH3SO3H
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 82956-11-4| Matching products
KEGG ID : K01340 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H361
P Phrases: P201, P202, P280, P308+313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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COVID-19 Research
Nafamostat . mesylate Nafamostat . mesylate
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