N-Formyl-Met-Leu-Phe

N-Formyl-Met-Leu-Phe (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPRs, Ki = 0.8 pM), which are mainly localized on polymorphonuclear and mononuclear phagocytes. Activation of FPRs by fMLF leads to cellular activation, which is characterized by cellular polarization, chemotaxis, and release of proteolytic enzymes. fMLF induces contractions in isolated guinea pig jejunum (EC50 = 11 nM), proximal colon (EC50 = 3.5 nM), and distal colon (EC50 = 2.2 nM). In vitro, fMLF induces neurotransmitter release from enteric motor neurons.Formal Name: N-formyl-L-methionyl-L-leucyl-L-phenylalanine. CAS Number: 59880-97-6. Synonyms: Chemotactic Peptide, fMLF, fMLP, NSC 350593. Molecular Formula: C21H31N3O5S. Formula Weight: 437.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: O=C(O)[C@@H](N([H])C([C@@H](N(C([C@@H](N(C=O)[H])CCSC)=O)[H])CC(C)C)=O)CC1=CC=CC=C1. InChi Code: InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1. InChi Key: PRQROPMIIGLWRP-BZSNNMDCSA-N.