N-desethyl Sunitinib

N-desethyl Sunitinib is an active metabolite of sunitinib (Cay-13159), a small molecule, multi-targeted receptor tyrosine kinase inhibitor. N-desethyl Sunitinib is formed when sunitinib undergoes N-de-ethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desethyl Sunitinib is pharmacologically active having similar inhibitory activity to sunitinib.Formal Name: N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- 1H-pyrrole-3-carboxamide. CAS Number: 356068-97-8. Synonyms: SU 12662. Molecular Formula: C20H23FN4O2. Formula Weight: 370.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): slightly soluble. lambdamax: 268, 429 nm. SMILES: CC1=C(/C=C2C(NC3=C\2C=C(F)C=C3)=O)NC(C)=C1C(NCCNCC)=O. InChi Code: InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-. InChi Key: LIZNIAKSBJKPQC-GDNBJRDFSA-N.