MU1210

MU1210 is an inhibitor of CDC-like kinase 1 (Clk1), Clk2, and Clk4 (IC50s = 8, 20, and 12 nM, respectively). It is selective for these kinases over Clk3 (IC50 = >3,000 nM), as well as dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK1B, DYRK2, homeodomain-interacting protein kinase 1 (HIPK1), and HIPK3 (IC50s = 213, 956, 1,309, 187, and 159 nM, respectively) but does inhibit HIPK2 (IC50 = 23 nM).Formal Name: 5-(1-methyl-1H-pyrazol-4-yl)-3-[3-(4-pyridinyl)phenyl]-furo[3,2-b]pyridine. CAS Number: 2275601-87-9. Molecular Formula: C22H16N4O. Formula Weight: 352.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml, Methanol: Slightly soluble: 0.1-1 mg/ml. SMILES: CN1C=C(C=N1)C2=NC3=C(C=C2)OC=C3C4=CC=CC(C5=CC=NC=C5)=C4. InChi Code: InChI=1S/C22H16N4O/c1-26-13-18(12-24-26)20-5-6-21-22(25-20)19(14-27-21)17-4-2-3-16(11-17)15-7-9-23-10-8-15/h2-14H,1H3. InChi Key: HEAGNKNMQVIVMM-UHFFFAOYSA-N.