MRTX-1257

Item number	Size	Delivery time	Price
TGM-T16143-1mg	1 mg	7 - 10 business days*	55.00€
TGM-T16143-2mg	2 mg	7 - 10 business days*	77.00€
TGM-T16143-5mg	5 mg	7 - 10 business days*	125.00€
TGM-T16143-1mL	1 ml	7 - 10 business days*	169.00€
TGM-T16143-10mg	10 mg	7 - 10 business days*	217.00€
TGM-T16143-25mg	25 mg	7 - 10 business days*	368.00€
TGM-T16143-50mg	50 mg	7 - 10 business days*	554.00€
TGM-T16143-100mg	100 mg	7 - 10 business days*	793.00€

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Description: MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an... more

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Product information "MRTX-1257"

Description: MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS-dependent ERK phosphorylation in H358 cells. MRTX-1257 demonstrated 31% bioavailability in the mouse, with free fraction exposures well above cellular potency, and 77% target engagement in a PK/PD experiment. Target: Ras. Smiles: CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C=C)c1cccc2cccc(C)c12

Supplier:	TargetMol
Supplier-Nr:	T16143

Properties

Application:	K-RasG12C covalent inhibitor
MW:	565.71 D
Formula:	C33H39N7O2

Database Information

CAS :	2206736-04-9\| Matching products
KEGG ID :	K07827 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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