MRTX-1257

MRTX-1257 is a covalent inhibitor of K-RasG12C. It inhibits proliferation of NCI H358 cells when used at concentrations ranging from 0.001 to 1 µM.Formal Name: (2S)-1-(1-oxo-2-propen-1-yl)-4-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-2-piperazineacetonitrile. CAS Number: 2206736-04-9. Molecular Formula: C33H39N7O2. Formula Weight: 565.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml. lambdamax: 226 nm. SMILES: CC1=CC=CC2=C1C(N3CC4=NC(OC[C@H]5N(C)CCC5)=NC(N6C[C@@H](N(CC6)C(C=C)=O)CC#N)=C4CC3)=CC=C2. InChi Code: InChI=1S/C33H39N7O2/c1-4-30(41)40-19-18-39(20-25(40)13-15-34)32-27-14-17-38(29-12-6-10-24-9-5-8-23(2)31(24)29)21-28(27)35-33(36-32)42-22-26-11-7-16-37(26)3/h4-6,8-10,12,25-26H,1,7,11,13-14,16-22H2,2-3H3/t25-,26-/m0/s1. InChi Key: YRYQLVCTQFBRLD-UIOOFZCWSA-N.