Modotuximab

Description: Modotuximab (DS 1024) is a humanized antibody targeting EGFR with antitumor activity that accelerates the intracellular internalization and degradation of EGFR by promoting cross-linking of EGFR on the cell surface. Target: EGFR. References: Keir ST, et al. Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models. J Neurooncol. 2018 Jul,138(3):489-498.