MMK1 (trifluoroacetate salt)

MMK1 is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1). MMK1 induces calcium flux in CHO cells expressing human FPR2 and Galpha16 (EC50 = alpha16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner. MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1beta and IL-6 in isolated human monocytes. Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.Formal Name: L-leucyl-L-alpha-glutamyl-L-seryl-L-isoleucyl-L-phenylalanyl-L-arginyl-L-seryl-L-leucyl-L-leucyl-L-phenylalanyl-L-arginyl-L-valyl-L-methionine, trifluoroacetate salt. Synonyms: LESIFRSLLFRVM, Leu-Glu-Ser-Ile-Phe-Arg-Ser-Leu-Leu-Phe-Arg-Val-Met. Molecular Formula: C75H123N19O18S . XCF3COOH. Formula Weight: 1611.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: soluble. SMILES: CC(C)C[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)CC2=CC=CC=C2)=O)([H])[C@@H](C)CC)=O)=O)=O)N[H].OC(C(F)(F)F)=O. InChi Code: InChI=1S/C75H123N19O18S.C2HF3O2/c1-12-44(10)60(94-70(108)57(39-96)92-63(101)50(27-28-58(97)98)83-61(99)47(76)33-40(2)3)72(110)90-55(37-46-23-17-14-18-24-46)68(106)84-48(25-19-30-81-74(77)78)62(100)91-56(38-95)69(107)88-53(35-42(6)7)65(103)87-52(34-41(4)5)66(104)89-54(36-45-21-15-13-16-22-45)67(105)85-49(26-20-31-82-75(79)80)64(102)93-59(43(8)9)71(109)86-51(73(111)112)29-32-113-11,3-2(4,5)1(6)7/h13-18,21-24,40-44,47-57,59-60,95-96H,12,19-20,25-39,76H2,1-11H3,(H,83,99)(H,84,106)(H,85,105)(H,86,109)(H,87,103)(H,88,107)(H,89,104)(H,90,110)(H,91,100)(H,92,101)(H,93,102)(H,94,108)(H,97,98)(H,111,112)(H4,77,78,81)(H4,79,80,82),(H,6,7)/t44-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-,60-,/m0./s1. InChi Key: XMPDJANNBKROKT-OTJWSKLVSA-N.