ML241 hydrochloride

Description: ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway-specific p97 inhibitors. Target: p97. Smiles: Cl.C(Nc1nc(nc2CCCCc12)N1CCOc2ccccc12)c1ccccc1. References: Chou TF, et al. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem. 2013 Feb,8(2):297-312.