ML-252 (hydrochloride)

ML-252 is a potent and selective inhibitor of the voltage-gated potassium channel subtype Kv7.2 (IC50 = 69 nM in a patch clamp assay). It is the (S)-enantiomer and is more potent than the (R)-enantiomer and the racemic mixture (IC50s = 944 and 160 nM, respectively). It is selective for Kv7.2 over other Kv channel subtypes, >68 G protein-coupled receptors, transporters, L- and N-type calcium channels, and KATP and hERG potassium channels though it does inhibit the melatonin MT1 receptor 61% when used at a concentration of 10 µM.Formal Name: (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide, monohydrochloride. CAS Number: 2309887-61-2. Molecular Formula: C20H24N2O . HCl. Formula Weight: 344.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 257, 304 nm. SMILES: CC[C@H](C(NC1=CC=CC=C1N2CCCC2)=O)C3=CC=CC=C3.Cl. InChi Code: InChI=1S/C20H24N2O.ClH/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22,/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23),1H/t17-,/m0./s1. InChi Key: XBYCQOZNTLUEDX-LMOVPXPDSA-N.