ML-154

ML-154 is an antagonist of the neuropeptide S receptor (NPSR, IC50 = 3.5 nM). It is selective for NPSR over arginine vasopressin (AVP) receptor V1B, as well as a panel of 55 receptors, channels, and transporters at 10 µM. ML-154 reduces NPS-induced calcium mobilization, cAMP formation, and ERK activation with IC50 values of 0.96, 45, and 1.3 nM, respectively, in CHO cells expressing NPSR. It reduces alcohol self-administration and the progressive ratio breakpoint, but not cue- or stress-induced reinstatement of alcohol-seeking behavior, in rats when administered intraperitoneally at a dose of 1 mg/kg. ML-154 (10 µg, i.c.v.) inhibits decreases in food intake induced by intracerebroventricular administration of NPS in rats.Formal Name: 3-(diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]-imidazo[1,2-a]pyridinium, monobromide. CAS Number: 1345964-89-7. Synonyms: NCGC84. Molecular Formula: C29H26N2PS . Br. Formula Weight: 545.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mg/ml, sonicated. SMILES: CC1=C(P(C2=CC=CC=C2)(C3=CC=CC=C3)=S)N4C=CC=CC4=[N+]1C/C=C/C5=CC=CC=C5.[Br-]. InChi Code: InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25,/h2-22H,23H2,1H3,1H/q+1,/p-1/b16-13+,. InChi Key: CJAQCMBWGUOBIX-ZUQRMPMESA-M.