ML-133 (hydrochloride)

ML-133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively). It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively). ML-133 (10 and 30 nmol/animal) prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury.Formal Name: N-[(4-methoxyphenyl)methyl]-1-naphthalenemethanamine, monohydrochloride. CAS Number: 1222781-70-5. Molecular Formula: C19H19NO . HCl. Formula Weight: 313.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 224 nm. SMILES: COC(C=C1)=CC=C1CNCC2=CC=CC3=C2C=CC=C3.Cl. InChi Code: InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17,/h2-12,20H,13-14H2,1H3,1H. InChi Key: NGQIBUUFXDPHKT-UHFFFAOYSA-N.