MK-886 (sodium salt)

MK-886 (sodium salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10133-1 1 mg -

6 - 10 business days*

Cay10133-5 5 mg -

6 - 10 business days*

Cay10133-10 10 mg -

6 - 10 business days*

Cay10133-25 25 mg -

6 - 10 business days*

Arachidonic acid (Cay-90010) and selected other polyunsaturated fatty acids are stereoselectively... more
Product information "MK-886 (sodium salt)"
Arachidonic acid (Cay-90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886 binds to FLAP with high-affinity and prevents 5-LO activation. MK-886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM. In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM. Formal Name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid, sodium salt. CAS Number: 118427-55-7. Molecular Formula: C27H33ClNO2S . Na. Formula Weight: 494.1. Purity: >99%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): .2 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 226, 289 nm. SMILES: CC(C)(C([O-])=O)CC1=C(SC(C)(C)C)C2=CC(C(C)C)=CC=C2N1CC3=CC=C(Cl)C=C3.[Na+]. InChi Code: InChI=1S/C27H34ClNO2S.Na/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18,/h8-14,17H,15-16H2,1-7H3,(H,30,31),/q,+1/p-1. InChi Key: CBNCIYNCWVGEKJ-UHFFFAOYSA-M.
Keywords: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-alpha,alpha-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid, sodium salt
Supplier: Cayman Chemical
Supplier-Nr: 10133


Application: Leukotriene biosynthesis inhibitor
MW: 494.1 D
Formula: C27H33ClNO2S . Na
Purity: >99%
Format: Crystalline Solid

Database Information

CAS : 118427-55-7| Find alternatives
KEGG ID : K00461 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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