Mitotane

Mitotane
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay18651-100 100 mg -

6 - 10 business days*

44.00€
Cay18651-250 250 mg -

6 - 10 business days*

77.00€
Cay18651-500 500 mg -

6 - 10 business days*

137.00€
Cay18651-1 1 g -

6 - 10 business days*

209.00€
 
Mitotane is an inhibitor of steroidogenesis. It decreases secretion of cortisol (Cay-20739) and... more
Product information "Mitotane"
Mitotane is an inhibitor of steroidogenesis. It decreases secretion of cortisol (Cay-20739) and 17-hydroxy progesterone (Cay-33154) from H295R adrenocortical carcinoma cells when used at a concentration of 50 µM. Mitotane also inhibits mitochondrial complex IV, also known as cytochrome c oxidase, activity in H295R cells (IC50 = 58 µM). It inhibits steroid production induced by adrenocorticotropic hormone (ACTH) and is cytotoxic to zona fasciculata and zona reticularis, but not zona glomerulosa, adrenal cortex cells in dogs when administered at a dose of 60 mg/kg. Formulations containing mitotane have been used in the treatment of adrenocortical carcinoma.Formal Name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene. CAS Number: 53-19-0. Synonyms: o,p'-DDD, 1,1-Dichlorodiphenildichloroethane, NSC 38721. Molecular Formula: C14H10Cl4. Formula Weight: 320.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 20 mg/ml. lambdamax: 229 nm. SMILES: ClC1=CC=C(C(C(Cl)Cl)C2=CC=CC=C2Cl)C=C1. InChi Code: InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H. InChi Key: JWBOIMRXGHLCPP-UHFFFAOYSA-N.
Keywords: o,p'-DDD, NSC 38721, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene
Supplier: Cayman Chemical
Supplier-Nr: 18651

Properties

Application: Steroidogenesis inhibitor
MW: 320 D
Formula: C14H10Cl4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 53-19-0| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H351
P Phrases: P201, P202, P280, P308+P313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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