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Mitotane is an inhibitor of steroidogenesis. It decreases secretion of cortisol (Cay-20739) and 17-hydroxy progesterone (Cay-33154) from H295R adrenocortical carcinoma cells when used at a concentration of 50 µM. Mitotane also inhibits mitochondrial complex IV, also known as cytochrome c oxidase, activity in H295R cells (IC50 = 58 µM). It inhibits steroid production induced by adrenocorticotropic hormone (ACTH) and is cytotoxic to zona fasciculata and zona reticularis, but not zona glomerulosa, adrenal cortex cells in dogs when administered at a dose of 60 mg/kg. Formulations containing mitotane have been used in the treatment of adrenocortical carcinoma.Formal Name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-benzene. CAS Number: 53-19-0. Synonyms: o,p'-DDD, 1,1-Dichlorodiphenildichloroethane, NSC 38721. Molecular Formula: C14H10Cl4. Formula Weight: 320.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 20 mg/ml. lambdamax: 229 nm. SMILES: ClC1=CC=C(C(C(Cl)Cl)C2=CC=CC=C2Cl)C=C1. InChi Code: InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H. InChi Key: JWBOIMRXGHLCPP-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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