Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13208-5 5 mg -

6 - 10 business days*

Cay13208-10 10 mg -

6 - 10 business days*

Cay13208-50 50 mg -

6 - 10 business days*

Cay13208-100 100 mg -

6 - 10 business days*

The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during... more
Product information "Mirin"
The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC50 = 66 µM). Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G2 arrest, abolishes the radiation-induced G2/M checkpoint, and prevents homology-directed repair of DNA damage. Formal Name: 2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone. CAS Number: 299953-00-7. Molecular Formula: C10H8N2O2S. Formula Weight: 220.3. Purity: >95%. Formulation: An orange crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.25 mg/ml. SMILES: N=C(S/C1=C\C2=CC=C(O)C=C2)NC1=O. InChi Code: InChI=1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-. InChi Key: YBHQCJILTOVLHD-YVMONPNESA-N.
Keywords: 2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
Supplier: Cayman Chemical
Supplier-Nr: 13208


Application: MRN complex inhibitor
MW: 220.3 D
Formula: C10H8N2O2S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 299953-00-7| Find alternatives
KEGG ID : K10865 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319
P Phrases: P264, P280, P305+351+338, P337+313
Our products are for laboratory research use only: Not for administration to humans!
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