Mirin

Mirin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13208-5 5 mg -

6 - 10 business days*

60.00€
Cay13208-10 10 mg -

6 - 10 business days*

113.00€
Cay13208-50 50 mg -

6 - 10 business days*

401.00€
Cay13208-100 100 mg -

6 - 10 business days*

683.00€
 
Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage... more
Product information "Mirin"
Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM). It inhibits phosphorylation of H2AX induced by DNA containing dsDNA breaks (DSBs), indicating decreased ATM activation, with an IC50 value of 66 µM in X. laevis cell-free extracts. Mirin (100 µM) also inhibits the exonuclease activity of Mre11 in a cell-free assay. It induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner. Nanoparticle-encapsulated mirin (50 mg/kg) reduces tumor growth in an LA-N-5 mouse xenograft model.Formal Name: 2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone. CAS Number: 299953-00-7. Molecular Formula: C10H8N2O2S. Formula Weight: 220.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 249, 353 nm. SMILES: N=C(S/C1=C\C2=CC=C(O)C=C2)NC1=O. InChi Code: InChI=1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-. InChi Key: YBHQCJILTOVLHD-YVMONPNESA-N.
Keywords: 2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
Supplier: Cayman Chemical
Supplier-Nr: 13208

Properties

Application: MRN complex inhibitor
MW: 220.3 D
Formula: C10H8N2O2S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 299953-00-7| Matching products
KEGG ID : K10865 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319
P Phrases: P264, P280, P305+P351+P338, P337+P313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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