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Item number: Cay13208-10

Mirin is an inhibitor of the Mre11/Rad50/Nbs1 (MRN) complex, which functions as a DNA damage sensor and activates the DNA repair enzyme ataxia-telangiectasia mutated kinase (ATM). It inhibits phosphorylation of H2AX induced by DNA containing dsDNA breaks (DSBs), indicating decreased ATM activation, with an IC50...

Keywords:	2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
Application:	MRN complex inhibitor
CAS	299953-00-7
MW:	220.3 D

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