MF766

MF766 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 (Ki = 0.23 nM). It is selective for EP4 over the PGD2 receptor subtype DP1 (Ki = 1,648 nM) as well as the EP1, EP2, EP3, and CRTH2/DP2 receptors, the PGI2 receptor (IP), thromboxane receptor (TP), and PGF receptor (FP, Kis = >6,000 nM for all). It inhibits cAMP accumulation induced by PGE2 (Cay-14010) in HEK293 cells (IC50 = 1.3 nM). MF766 (312.5 and 1,250 nM) reverses PGE2-induced decreases in IFN-gamma production in IL-2-stimulated primary human natural killer cells. It reduces paw edema in a rat model of adjuvant-induced arthritis in a dose-dependent manner. MF766 (30 mg/kg) inhibits tumor growth in a CT26 murine colon cancer model.Formal Name: 4-[1-[[[1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indol-7-yl]carbonyl]amino]cyclopropyl]-benzoic acid. CAS Number: 1050656-06-8. Molecular Formula: C27H21F3N2O3. Formula Weight: 478.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 228 nm. SMILES: O=C(C1=CC=C(C2(CC2)NC(C3=CC=CC4=C3N(CC5=CC=C(C(F)(F)F)C=C5)C=C4)=O)C=C1)O. InChi Code: InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35). InChi Key: BWXAZFCPGFKANL-UHFFFAOYSA-N.