Metoclopramide (hydrochloride)

Metoclopramide is a dual antagonist of the serotonin (5-HT) receptor subtype 5-HT3 and dopamine D2 receptor (IC50s = 308 and 483 nM, respectively). It also reversibly inhibits acetylcholinesterase (AChE) isolated from human postmortem caudate nucleus (Kis = 9.3 and 82 µM for competitive and non-competitive inhibition, respectively). Oral administration of metoclopramide inhibits emesis induced by the DNA cross-linking agent cisplatin (Cay-13119) in ferrets (ED50 = 6,170 µg/kg) and the dopamine receptor agonist apomorphine in dogs (ED50 = 0.45 mg/kg). Metoclopramide also inhibits apomorphine-induced climbing and stereotypy in mice (ED50s = 2.2 and 6.5 mg/kg, respectively). Formulations containing metoclopramide have been used in the treatment of gastroesophageal reflux disease (GERD) and diabetic gastroparesis.Formal Name: 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide, monohydrochloride. CAS Number: 7232-21-5. Synonyms: NSC 354467. Molecular Formula: C14H22ClN3O2 . HCl. Formula Weight: 336.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 213, 233, 278, 312 nm. SMILES: ClC1=CC(C(NCCN(CC)CC)=O)=C(OC)C=C1N.Cl. InChi Code: InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3,/h8-9H,4-7,16H2,1-3H3,(H,17,19),1H. InChi Key: RVFUNJWWXKCWNS-UHFFFAOYSA-N.