MeTC7

MeTC7 is a vitamin D receptor antagonist (IC50 = 2.9 µM in a fluorescence polarization assay). It inhibits vitamin D receptor transactivation in HEK293 cells (IC50 = 20.8 µM). It decreases the viability of OVCAR-8, OV-2008, SKOV3, Caov-3, and IGROV-1 ovarian cancer cells in a concentration-dependent manner. MeTC7 (250 nM) reduces retinoid X receptor alpha (RXRalpha) and importin-4 protein levels in OV-2008 cells. It reduces tumor growth in an SH-SY5Y neuroblastoma mouse xenograft model when administered at a dose of 10 mg/kg.Formal Name: 2-bromo-acetic acid, (6S,8aR,8bR,10aR,11R,13aR)-11-[(1R)-1,5-dimethylhexyl]-2,3,5,6,7,8,8a,8b,10,10a,11,12,13,13a-tetradecahydro-2,8a,10a-trimethyl-1,3-dioxo-4a,13b-etheno-1H,9H-benzo[c]cyclopenta[h][1,2,4]triazolo[1,2-a]cinnolin-6-yl ester. CAS Number: 1817841-22-7. Molecular Formula: C32H48BrN3O4. Formula Weight: 618.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 1 mg/ml. SMILES: C[C@@]12[C@](C=C[C@@]34C2CC[C@@]5(C)[C@@]3([H])CC[C@]5([H])[C@@H](CCCC(C)C)C)(N6C(N(C)C(N64)=O)=O)C[C@@H](OC(CBr)=O)CC1. InChi Code: InChI=1S/C32H48BrN3O4/c1-20(2)8-7-9-21(3)23-10-11-24-29(23,4)14-13-25-30(5)15-12-22(40-26(37)19-33)18-31(30)16-17-32(24,25)36-28(39)34(6)27(38)35(31)36/h16-17,20-25H,7-15,18-19H2,1-6H3/t21-,22+,23-,24-,25?,29-,30-,31-,32+/m1/s1. InChi Key: LBFDLJSQMPCWKK-RBRUHCLLSA-N.