138 products were found matching "K08539"!

Vitamin D3 is a biologically inactive precursor to calcitriol (Cay-71820) that is converted to active metabolites in vivo. Vitamin D3 is obtained from dietary sources, including fish, or formed in the epidermis via photolytic conversion of 7-dehydro cholesterol (Cay-14612) to previtamin D3 by UVB radiation, followed...

Rabbit Polyclonal VDR Antibody against Human vitamin D receptor. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000022479: 99%, ENSRNOG00000054420: 99%....

The active hormonal form of vitamin D3. Induces cell differentiation and prevents proliferation of cancer cells. Along with dietary calcium, reduces the risk of colon cancer.

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity. Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-dehydrocholesterol to vitamin D3 by ultraviolet...

Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also...

Protein function: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the...

Isotope Incorporation: >98%

1,25-dihydroxy Vitamin D2 is the active circulating metabolite of vitamin D2 formed by 25-hydroxylase in the liver and 25-hydroxyvitamin D-hydroxylase in the kidney. By binding to the vitamin D receptor (VDR), 1,25-dihydroxy Vitamin D2 activates VDR to interact with the retinoid X receptor (RXR), forming the...

Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer, and immunity. In addition, the active form of vitamin D, 1,25-dihydroxy vitamin D3, decreases the proliferation and increases differentiation of keratinocytes. 1,24-dihydroxy Vitamin D3 is an...

EB 1089 is a synthetic vitamin D analog that is 50-200 times more potent than calcitriol (Cay-71820) at inhibiting cell proliferation and differentiation, yet displays reduced calcemic activity compared to that of calcitriol. It has been shown to promote tumor regression in vitro by inducing apoptosis.Formal Name:...

Calcitriol-d6 is intended for use as an internal standard for the quantification of calcitriol (Cay-71820) by GC- or LC-MS. Calcitriol is a vitamin D3 receptor agonist and an active metabolite of vitamin D3 (Cay-11792). It is formed via a multi-step process, in which vitamin D3 undergoes hydroxylation to 25-hydroxy...

Vitamin D4 is a vitamin produced in fungi from the UV irradiation of 22,23-dihydroergosterol (Provitamin D4). It is produced by several mushroom species including A. bisporus, F. velutipes, G. frondose, and C. cibarius and in S. cerevisiae. Vitamin D4 is 60% as active as vitamin D3 (Cay-11792) at healing rickets in...