Metaproterenol (hemisulfate)

Metaproterenol is a beta2-adrenergic receptor (beta2-AR) agonist with bronchodilator actions. It inhibits TGF-alpha-induced hepatocyte DNA synthesis and proliferation in vitro (IC50 = 15 nM), an effect that is reversed by the beta2-AR antagonist butoxamine but not the beta1-AR antagonist metoprolol (Cay-15429). Metaproterenol dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively). Formulations containing metaproterenol were previously used as long-acting bronchodilators for the treatment of asthma.Formal Name: 5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-1,3-benzenediol, hemisulfate. CAS Number: 5874-97-5. Synonyms: dl-Metaproterenol, dl-Orciprenaline. Molecular Formula: C11H17NO3 . 1/2H2SO4. Formula Weight: 260.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: OC1=CC(O)=CC(C(CNC(C)C)O)=C1.OC2=CC(O)=CC(C(CNC(C)C)O)=C2.O=S(O)(O)=O. InChi Code: InChI=1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8,1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3,(H2,1,2,3,4). InChi Key: MKFFGUZYVNDHIH-UHFFFAOYSA-N.