Mepenzolate (bromide)

Mepenzolate is an antagonist of muscarinic (M) acetylcholine receptors (Kis = 0.68 and 2.6 nM for human M2 and M3 receptors, respectively). It has antispasmodic activity in the gastrointestinal tract of anesthetized cats and dogs when administered at a dose of 0.5 mg/kg. Mepenzolate decreases airspace enlargement induced by elastase or cigarette smoke and reduces respiratory dysfunction in a mouse model of chronic obstructive pulmonary disease (COPD). It also reduces oxidative stress, decreases the expression of IL-1beta, IL-6, and TNF-alpha, and increases the expression of TGF-beta1, IGF-1, and VEGF in a diabetic wound healing mouse model.Formal Name: 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-piperidinium, monobromide. CAS Number: 76-90-4. Synonyms: NSC 4358. Molecular Formula: C21H26NO3 . Br. Formula Weight: 420.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: C[N+]1(C)CCCC(OC(C(O)(C2=CC=CC=C2)C3=CC=CC=C3)=O)C1.[Br-]. InChi Code: InChI=1S/C21H26NO3.BrH/c1-22(2)15-9-14-19(16-22)25-20(23)21(24,17-10-5-3-6-11-17)18-12-7-4-8-13-18,/h3-8,10-13,19,24H,9,14-16H2,1-2H3,1H/q+1,/p-1. InChi Key: JRRNZNSGDSFFIR-UHFFFAOYSA-M.