MEK1, 2 Inhibitor (U0126, Bis[amino[(2-aminophenyl)thio]methylene]Butanedinitrile)

Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays. In aqueous and certain organic solvents M2865-50A exists as an equilibrium mixture of 2 isomers which cannot be permanently separated. The 2 individual isomers have equivalent biological activity because they give rise to the same equilibrium mixture of isomes in aqueous solutions. Synonyms: MEK1, 2 Inhibitor,, Bis[amino[(2-aminophenyl)thio]methylene]Butanedinitrile), 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene, CAS No: 109511-58-2, Molecular Formula: C18H16N6S2, Molecular Weight: 380.49, Appearance: Supplied as a white powder. Purity: >99% (HPLC, TLC), Solubility: Soluble in DMSO at 200mg/ml. Very poorly soluble in ethanol and water. Maximum solubility in plain water is estimated to be about 10-50uM. Melting Point: 130-132.5ºC, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.