U-0126

U-0126
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70970-1 1 mg -

6 - 10 business days*

44.00€
Cay70970-5 5 mg -

6 - 10 business days*

120.00€
Cay70970-10 10 mg -

6 - 10 business days*

219.00€
Cay70970-25 25 mg -

6 - 10 business days*

383.00€
 
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. It... more
Product information "U-0126"
U-0126 is a MEK inhibitor with IC50 values of 72 nM and 58 nM for MEK1 and MEK2, respectively. It is noncompetitive with respect adenosine triphosphate (ATP) and its phosphorylation target ERK and it shows little to no inhibition against a number of other kinases including PKC, Ab1, Raf, MEKK, ERK, JNK, MKK-3, MKK-4, MKK-6, Cdk2, and Cdk4. However, U-0126 does phosphorylate and activate AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 15 µM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC). Formal Name: 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile. CAS Number: 109511-58-2. Molecular Formula: C18H16N6S2. Formula Weight: 380.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMF: PBS (pH 7.2)(1:2): 0.3 mg/ml, DMSO: 25 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 247, 308 nm. SMILES: N/C(SC1=CC=CC=C1N)=C(C#N)\C(C#N)=C(N)\SC2=C(N)C=CC=C2. InChi Code: InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+. InChi Key: DVEXZJFMOKTQEZ-JYFOCSDGSA-N.
Keywords: 2,3-bis[amino[(2-aminophenyl)thio]methylene]-butanedinitrile
Supplier: Cayman Chemical
Supplier-Nr: 70970

Properties

Application: MEK inhibitor
MW: 380.5 D
Formula: C18H16N6S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 109511-58-2| Find alternatives
KEGG ID : K04368 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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