MEGX (hydrochloride)

MEGX is an active metabolite of lidocaine. It is formed via N-deethylation of lidocaine by the hepatic cytochrome P450 (CYP) isoform CYP3A4. Topical administration of MEGX (2% v/v) reduces thrombus formation in a hamster model of laser-induced microvascular injury. Plasma levels of MEGX following lidocaine administration have been used to monitor declining liver function in patients with cirrhosis.Formal Name: N-(2,6-dimethylphenyl)-2-(ethylamino)-acetamide, monohydrochloride. CAS Number: 7729-94-4. Synonyms: Monoethylglycinexylidide, Norlidocaine. Molecular Formula: C12H18N2O . HCl. Formula Weight: 242.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: CC1=CC=CC(C)=C1NC(CNCC)=O.Cl. InChi Code: InChI=1S/C12H18N2O.ClH/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3,/h5-7,13H,4,8H2,1-3H3,(H,14,15),1H. InChi Key: KPXFVVHMUVBVGI-UHFFFAOYSA-N.