MD-224

Item number	Size	Manual	SDS	Delivery time	Price
Cay40960-500	500 µg	-	-	6 - 10 business days*	68.00€
Cay40960-1	1 mg	-	-	6 - 10 business days*	128.00€
Cay40960-5	5 mg	-	-	6 - 10 business days*	267.00€

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A PROTAC that drives MDM2 degradation, induces degradation of MDM2, which increases p53 levels,... more

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Product information "MD-224"

A PROTAC that drives MDM2 degradation, induces degradation of MDM2, which increases p53 levels, in RS4,11 cells at 10 nM, inhibits the growth of RS4,11 cells (IC50 = 1.5 nM), induces complete tumor regression and does not affect body weight in an RS4,11 mouse xenograft model at 50 mg/kg every other day for three weeks

Keywords:	(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[4-[[[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-4-pentyn-1-yl]amino]carbonyl]phenyl]-1'',2''-dihydro-2''-oxo-dispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indole]-5'-carbox
Supplier:	Cayman Chemical
Supplier-Nr:	40960

Properties

Application:	MDM2 degradation driving PROTAC
MW:	889.8 D
Formula:	C48H43Cl2FN6O6
Purity:	>95%
Format:	Solid

Database Information

CAS :	2136247-12-4\| Matching products
KEGG ID :	K06643 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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