MC3482 (trifluoroacetate salt)

MC3482 is an inhibitor of sirtuin 5 (SIRT5). It is selective for SIRT5 over SIRT1 and SIRT3 at 50 µM. MC3482 (50 µM) induces autophagy and mitophagy in MDA-MB-231 cells and decreases lipid droplet size and increases lipolysis and the oxygen consumption rate (OCR) in differentiated 3T3-L1 adipocytes. In vivo, MC3482 (2 mg/kg) decreases brain water content, infarct volume, and neurological deficits in a mouse model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO). It decreases airway hyperresponsiveness, serum IgE levels, neutrophil and eosinophil bronchoalveolar lavage fluid (BALF) infiltration, epithelial hyperplasia, and mucus production in a mouse model of toluene-2,4-diisocyanate-induced asthma. MC3482 increases the paw withdrawal threshold in a mouse model of complete Freund's adjuvant-induced inflammatory pain. Formal Name: (3S,12S)-12-carboxy-9,14-dioxo-16-phenyl-3-[(phenylamino)carbonyl]-15-oxa-2,8,13-triazahexadecanoic acid, 1-(phenylmethyl) ester, trifluoroacetate salt. Molecular Formula: C33H38N4O8  XCF3COOH. Formula Weight: 618.7. Purity: >85%. Formulation (Request formulation change): A solid. Solubility: DMSO: Soluble: >10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(NCCCC[C@@H](C(NC1=CC=CC=C1)=O)NC(OCC2=CC=CC=C2)=O)CC[C@H](NC(OCC3=CC=CC=C3)=O)C(O)=O.O=C(O)C(F)(F)F. InChi Code: InChI=1S/C33H38N4O8.C2HF3O2/c38-29(20-19-28(31(40)41)37-33(43)45-23-25-14-6-2-7-15-25)34-21-11-10-18-27(30(39)35-26-16-8-3-9-17-26)36-32(42)44-22-24-12-4-1-5-13-24,3-2(4,5)1(6)7/h1-9,12-17,27-28H,10-11,18-23H2,(H,34,38)(H,35,39)(H,36,42)(H,37,43)(H,40,41),(H,6,7)/t27-,28-,/m0./s1. InChi Key: AKGNNEKWORAHPU-DHBRAOIWSA-N. Storage: -20°C. Stability: > 4 years.