66 products were found matching "K11415"!

MC3482 is an inhibitor of sirtuin 5 (SIRT5). It is selective for SIRT5 over SIRT1 and SIRT3 at 50 µM. MC3482 (50 µM) induces autophagy and mitophagy in MDA-MB-231 cells and decreases lipid droplet size and increases lipolysis and the oxygen consumption rate (OCR) in differentiated 3T3-L1 adipocytes. In vivo, MC3482...

Active human Sirtuin 5 (GenBank Accession No. NM_012241), full length with N-terminal GST tag, MW= 59.8 kDa, expressed in E. coli expression system.

Sirtuin 5 (SIRT5) is an enzyme that catalyzes the NAD-dependent removal of malonyl, succinyl, and glutaryl groups from target proteins. Although it was originally characterized as a class III histone deacetylase (HDAC), SIRT5 exhibits weak NAD-dependent deacetylase activity in vitro and in vivo. SIRT5 is localized...

Protein function: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged...

The Fluorogenic SIRT5 Assay Kit is a complete assay system designed to measure SIRT5 activity for screening and profiling applications. It comes in a convenient 96-well format, with all the reagents necessary for 100 fluorescent SIRT5 activity measurements. In addition, the kit includes purified SIRT5 enzyme and a...

Anti-SIRT5 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-SIRT5 from human, mouse and rat based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-SIRT5 from other sources has not been determined. Protein function:...

Anti-SIRT5 Antibody is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above. Cross reactivity with SIRT5 from other sources has not been determined....

In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however,...

In 1X PBS, pH 7.4, with 0.09% sodium azide. SIRT5 is an NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by...

Protein function: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and...

Protein function: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during...